What Is Selank?
Selank (CAS 129954-34-3) is a synthetic heptapeptide derived from the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), with the addition of a Pro-Gly-Pro stabilizing sequence at the C-terminus. Its full amino acid sequence is Thr-Lys-Pro-Arg-Pro-Gly-Pro, yielding a molecular weight of 751.87 Da and a molecular formula of C33H57N9O9. Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in collaboration with the V.V. Zakusov Research Institute of Pharmacology during the 1990s.
Classified as a nootropic and anxiolytic peptide, Selank has been the subject of extensive preclinical investigation and is of particular interest to researchers studying the neurochemical basis of anxiety, cognitive enhancement, and immune regulation. The peptide’s dual profile combining potential anxiolytic effects with immunomodulatory activity distinguishes it from conventional single-target compounds in the cognitive and nootropic peptide category.
Selank is supplied exclusively for research use only (RUO). It has not been approved by the FDA for any human therapeutic application. Wholesale buyers seeking Selank for institutional or commercial research can access volume pricing through our wholesale peptide program.
Mechanism of Action
Selank’s mechanism of action is multifaceted, engaging several neurochemical and immunological pathways simultaneously. At the neurochemical level, researchers have documented the peptide’s influence on the monoamine neurotransmitter system. Studies in animal models demonstrate that Selank modulates the metabolism of serotonin (5-HT) and its metabolite 5-HIAA in brain structures including the hypothalamus, hippocampus, and frontal cortex. This serotonergic modulation is hypothesized to underlie its observed anxiolytic-like effects in behavioral paradigms such as the elevated plus maze and open field tests.
In parallel, Selank has been shown to influence BDNF (brain-derived neurotrophic factor) expression in the hippocampus. BDNF is a critical neurotrophin involved in synaptic plasticity, long-term potentiation, and neuronal survival. Upregulation of BDNF represents a plausible mechanism for the cognitive-enhancing effects reported in preclinical models. Additionally, Selank has been studied for its effects on the enkephalin-degrading enzymes, potentially prolonging the activity of endogenous opioid peptides involved in stress response and emotional regulation.
From an immunological perspective, Selank inherits and extends the immunomodulatory activity of its parent molecule tuftsin. It has been observed to modulate IL-6, TNF-alpha, and other cytokine expression profiles, suggesting a regulatory rather than purely stimulatory or suppressive effect on immune function. This dual neuro-immune profile makes Selank relevant to researchers studying psychoneuroimmunology. Related nootropic compounds such as Epitalon and neuropeptides like PT-141/Bremelanotide are frequently studied in parallel for overlapping receptor pathway analysis.
Research Applications
Selank has been investigated in numerous preclinical research contexts spanning neuroscience, immunology, and molecular pharmacology:
Anxiety and Stress Response Research
Researchers have studied Selank extensively in animal models of anxiety. In the elevated plus maze, a standard behavioral test for anxiolytic activity, Selank administration has been associated with increased exploration of open arms without sedation or motor impairment, distinguishing its profile from classical benzodiazepines. These findings position Selank as a valuable tool compound for investigating non-GABAergic mechanisms of anxiolysis.
Cognitive Function and Memory
Preclinical data indicate that Selank may enhance learning and memory consolidation in passive avoidance and Morris water maze paradigms. Researchers have investigated its effects on hippocampal gene expression, documenting changes in over 40 genes associated with synaptic plasticity, neurotransmission, and protein biosynthesis. These genomic-level observations provide a molecular basis for the cognitive effects observed behaviorally.
Immunomodulatory Research
Selank has been studied in animal models for its effects on innate and adaptive immune function. Researchers have documented altered expression of genes involved in inflammatory signaling, chemokine production, and T-cell regulation. This immunomodulatory dimension makes Selank relevant to immune-regulatory peptide research programs, particularly those studying the neuro-immune axis.
Neuroprotection
Emerging preclinical studies have examined Selank in models of neurotoxicity and neurodegeneration. Observed effects include modulation of oxidative stress markers and protection of neuronal viability under excitotoxic conditions. Researchers frequently pair Selank with other neuroprotective agents such as SS-31/Elamipretide for comparative mitochondrial and synaptic studies.
For laboratories conducting large-scale behavioral studies or multi-arm cognitive trials, visit the Selank wholesale pricing page.
Available Formats and Bulk Options
Wholesale Bulk Peptides offers Selank in research-ready formats:
- 5 mg lyophilized vials — suitable for pilot studies, binding assays, and initial dose-finding experiments
- 10 mg lyophilized vials — optimized for chronic dosing studies and behavioral research protocols requiring sustained administration
- Bulk lyophilized powder — available in gram quantities for CROs, academic core facilities, and private-label peptide brands
Custom formulations and packaging configurations are available for qualified wholesale accounts. Apply through our wholesale program portal to access institutional pricing.
Wholesale Pricing Summary
Selank wholesale pricing is structured on a volume-tiered basis to serve peptide resellers, research institutions, and contract research organizations. Volume discounts increase substantially at higher quantity commitments. For complete pricing tables, lead times, and minimum order quantities, visit the Selank wholesale page. New wholesale accounts can apply through the wholesale program application.
Quality Assurance, Testing, and COAs
Every batch of Selank undergoes comprehensive analytical verification before release:
- HPLC (High-Performance Liquid Chromatography) — validates purity of 98% or greater with full chromatographic profiles
- Mass Spectrometry (MS) — confirms observed molecular weight matches the theoretical mass of 751.87 Da
- Amino Acid Analysis — quantifies the Thr-Lys-Pro-Arg-Pro-Gly-Pro sequence composition
- Endotoxin Testing (LAL) — ensures compliance with endotoxin thresholds required for in vivo research
Batch-specific COAs are included with every shipment and are accessible through our COA library. For detailed information on our analytical testing protocols, visit our testing methodology page. Learn how to evaluate peptide quality documentation with our Peptide COA Guide.
Storage and Stability
Selank lyophilized powder should be stored at -20 degrees Celsius in a sealed, desiccated container protected from light. Under these conditions, stability is maintained for a minimum of 24 months. Reconstituted solutions should be stored at 2-8 degrees Celsius and consumed within 14-21 days. Use sterile, filtered bacteriostatic water or normal saline for reconstitution. Avoid repeated freeze-thaw cycles and aliquot reconstituted peptide into single-use volumes immediately after preparation. For bulk powder orders, subdivide into smaller working lots upon receipt to minimize exposure to ambient conditions.
Compliance and Intended Use
Selank is sold by Wholesale Bulk Peptides exclusively for research use only (RUO). This peptide is not intended for use as a drug, dietary supplement, food additive, or cosmetic ingredient. It has not been evaluated or approved by the U.S. FDA or any equivalent regulatory agency for diagnostic or therapeutic use in humans or animals. All purchasers are responsible for ensuring that their use of Selank complies with applicable institutional review board (IRB) protocols, local regulations, and federal guidelines governing research materials.
Related Compounds
Researchers working with Selank frequently investigate complementary compounds targeting cognitive function, neuroprotection, and immune modulation:
- Epitalon — a tetrapeptide studied for telomerase activation and neuroendocrine regulation in aging models
- KPV — an anti-inflammatory tripeptide derived from alpha-MSH, studied for immune-regulatory effects
- SS-31/Elamipretide — a mitochondria-targeted peptide with neuroprotective research applications
- BPC-157 — a gastric pentadecapeptide with broad preclinical data on tissue-protective effects including neuroprotection
Explore the full cognitive and nootropic peptide catalog to source multi-compound research panels. Planning to launch a peptide brand? See our Start a Peptide Brand guide.
Frequently Asked Questions About Selank
Our team addresses the most common technical and logistical questions from wholesale Selank buyers covering reconstitution protocols, bulk packaging options, analytical documentation, and shipping requirements. For product-specific inquiries, see the Selank wholesale page. For general program information, visit the wholesale peptides hub.
Disclaimer: This material is provided for informational and research purposes only. Selank is sold as a Research Use Only (RUO) compound. It is not intended for human or veterinary diagnostic or therapeutic use. All buyers are responsible for ensuring compliance with applicable laws and institutional guidelines. Wholesale Bulk Peptides makes no claims regarding the safety or efficacy of this compound for any purpose other than qualified laboratory research.